49 Marlborough was designed by architect Samuel D. Kelley and built in 1889 by Warren Dexter Vinal, a builder and real estate developer, one of four contiguous houses (424 Marlborough and 47-49-51 Massachusetts Avenue). He is shown as the owner on the original building permit applications, all dated March 1, 1889, and on the final building inspection report for 51 Massachusetts Avenue, dated November 15, 1889. On the application for 49 Massachusetts Avenue, the address is shown as 442 West Chester Park; it changed to 49 Massachusetts Avenue when West Chester Park was renamed on March 1, 1894.
By the 1890-1891 winter season, 49 Massachusetts Avenue was the home of Mrs. Alice (Spring) Blake, the widow of banker James Henry Blake, and their son, Henry Spring Blake. They previously had lived at 193 Beacon, where James Blake had died in November of 1889.
T. Niles et al are shown as the owners on the 1895 Bromley map, George E. Niles et al, trustees, are shown as the owners on the 1898 map, and F. C. Welch et al, trustees, are shown as the owners on the 1908 and 1917 maps.
Alice Blake died in June of 1923. Henry Blake, a stockbroker, moved to the Hotel Somerset and, in July of 1923, married to Mrs. Lucie (Mitchell) Seeley Lawson, the former wife of Herbert Barnum Seeley and of Arnold Lawson. After their marriage, they lived in an apartment at 481 Beacon.
By 1924, 49 Massachusetts Avenue was owned by real estate dealer Edward J. Ball. He also owned 47 Massachusetts Avenue. In March of 1924, he applied for (and subsequently received) permission to convert 49 Massachusetts Avenue into a multiple dwelling and store, lowering the first floor to street level and installing a storefront. At about the same time, he also installed a storefront at 47 Marlborough (it already was a multiple dwelling).
In the fall of 1926, Napoleon L. Demara of Lawrence purchased 47-49 Massachusetts Avenue from Edward Ball. The transaction was reported in the Boston Globe on October 3, 1926, which indicated that the combined property “comprises the large brick building containing four stores on the lower floor and apartments above.”
N. L. Demara is shown as the owner of 47-49 Massachusetts Avenue on the 1928 and 1938 Bromley maps.
By 1965, 47-49 Massachusetts Avenue were owned by Morris Bernstein, a lawyer, who lived in Newton.
In October of 1977, Despina (Kalogeras) Mourlas, trustee of the Despina Realty Trust, purchased 47-49 Massachusetts Ave. from Sara Bernstein and Evelyn Bernstein.
In March of 1978, Despina Mourlas filed for permission to consolidate 47 and 49 Massachusetts Avenue into one property, with the combined occupancy of six apartments, a retail store, and restaurant. She subsequently abandoned her application.
She married again in the mid-1980s to George S. Tzantzos.
In November of 1987, she transferred the property to herself as trustee of a newly organized Despina Realty Trust. The transfer was made with the consent of her children, who were the beneficiaries of the former trust: Constantine Mourlas, Alexander (Spiros) Mourlas, and Anthony (Antonios) Mourlas.
47-49 Marlborough continued to be a residential and commercial buildings, with a common ownership, in 2014.